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pentobarbital will reduce the extent or effect of guanfacine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Potent or moderate CYP3A4 inducers noticeably lower guanfacine plasma concentrations and elimination 50 percent-lifetime.pentobarbital will reduce the level or result of brexpiprazole by affecting he